The Genetic Structure of Populations Changes across Space and Time As population geneticists discovered that most populations harbor considerable genetic diversity, they also found that the genetic structure of populations varies across space and time. To illustrate, we consider studies on Drosophila pseudoobscura conducted by Theodosius Dobzhansky and his colleagues. This species is found over a wide range of environmental habitats, including the western and southwestern United States. Although the flies throughout this range are morphologically similar, Dobzhansky's team discovered that populations from different locations vary in the arrangement of genes on chromosome 3. They found several different inversions in this chromosome that can be detected by loop formations in larval polytene chromosomes. Each inversion sequence is named after the locale in which it was first discovered (e.g., AR = Arrowhead, British Columbia, and CH = Chiricahua Mountains, Arizona). The inversion sequences were compared with one standard sequence, arbitrarily designated ST. [Page 645] Figure 26-4 compares the frequencies of three arrangements