In late 1986, a Florida dentist tested positive for HIV. Several months later, he was diagnosed with AIDS. He continued to practice general dentistry for two more years, until one of his patients, a young woman with no known risk factors, discovered that she, too, was infected with HIV. When the dentist publicly urged his other patients to have themselves tested, several more were found to be HIV positive. Did this dentist transmit HIV to his patients, or did the patients become infected by some other means? At first glance, this situation appears to be a long way from a discussion of evolution; however, the movement of a virus from one individual to another is similar to the founding of a new island population by a small number of migrants. Gene flow between the ancestral population and the new population is nonexistent, and the populations are free to diverge, as a result of genetic drift, adaptation to different environments, or both. If the dentist passed his HIV infection to his patients, then the