A Method for Estimating Evolutionary Trees from Genetic Data Many methods use data on genetic differences to estimate phylogenies. It is beyond the scope of this chapter to review all of them. Instead, we shall present just one method, called the unweighted pair group method using arithmetic averages, or UPGMA. This method is not the most powerful one for estimating phylogenies from genetic data, but, in spite of its lengthy name, it is intuitively straightforward. Furthermore, UPGMA works reasonably well under many circumstances. [Page 654] The starting point for UPGMA is a table of genetic distances among a group of species [Figure 26-19(a)]. To demonstrate the technique, we will use data from DNA hybridization studies by Charles Sibley and Jon Alquist, who computed genetic distances between humans and four species of apes: the common chimpanzee, the gorilla, the siamang, and the common gibbon. Figure 26-19. Phylogeny reconstruction by UPGMA. (This item is displayed on page 655 in the print version) [View full size image]