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Part 4: Genomic Analysis Regulation of Gene Expression in Prokaryotes Review
  1. Prokaryotes respond to environmental conditions by regulating transcription via , , or control.
  2. In E. coli, lactose metabolism is regulated by control of an system, where is the inducer.
    • Expression of the lac operon is also subject to positive control: the operon is by the catabolite-activating protein (CAP), together with Cyclic adenosine monophosphate ( cAMP ) when is absent.
    • Binding of the repressor to the forms a loop in the lac operon DNA.
  3. The E. coli tryptophan (trp) operon is a system that is repressed by of the transcript.
    • Bacillus subtilis uses a combination of and AT proteins to regulate its trp operon via .
  4. The arabinose (a monosaccharide) operon is subject to both positive and negative regulation by the protein.
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