Summary of DNA synthesis in bacteria.
<LI> At the advancing fork, helicase proteins unwind the double helix.
<LI> Primase lays down a short RNA primer.
<LI> Each  core  enzyme  of  the DNA polymerase III dimer is bound to a
template strand by a beta-subunit sliding clamp.
<LI> Synthesis  is  continuous  on  the  leading  strand, but occurs in
Okazaki fragments on the lagging strand.
<LI> The  lagging  strand loops around to allow concurrent synthesis on
both strands.
<LI> DNA  polymerase I replaces the RNA primer (synthesized by primase)
with DNA.
<LI> DNA ligase joins the Okazaki fragments.